English editorial summary of the original Hebrew article.
CIP is a controlled cleaning process for production equipment, piping and vessels without dismantling them. Cleaning solutions circulate through the system under defined conditions.
System design considers sanitary construction, complete coverage, flow, temperature and chemical concentration. The cleaning programme must be suited to the product and equipment.
SIP uses steam to sterilize the system. The cycle and its validation must account for heat distribution, exposure time and the requirements of the aseptic process.