English editorial summary of the original Hebrew article.
Cleanrooms control contamination to protect pharmaceutical and biotechnology products. Their design combines air systems, material selection, people and material flows, monitoring and maintenance.
Cleanroom grades and ISO classifications describe different cleanliness requirements. The appropriate conditions depend on the operation and its risk to the product.
Qualification and ongoing monitoring are needed to verify performance. Airflow, filtration, environmental monitoring and cleaning all form part of the contamination control approach.